43,507 research outputs found

    Antidote application: an educational system for treatment of common toxin overdose

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    Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae. Current toxicological resources that support treatment decisions are broad in scope, time-consuming to read, or at times unavailable. Our review of current toxicological resources revealed a gap in their ability to provide expedient calculations and recommendations about appropriate course of treatment. To bridge the gap, we developed the Antidote Application (AA), a computational system that automatically provides patient-specific antidote treatment recommendations and individualized dose calculations. We implemented 27 algorithms that describe FDA (the US Food and Drug Administration) approved use and evidence-based practices found in primary literature for the treatment of common toxin exposure. The AA covers 29 antidotes recommended by Poison Control and toxicology experts, 19 poison classes and 31 poisons, which represent over 200 toxic entities. To the best of our knowledge, the AA is the first educational decision support system in toxicology that provides patient-specific treatment recommendations and drug dose calculations. The AA is publicly available at http://projects.met- hilab.org/antidote/

    The interpretation of the field angle dependence of the critical current in defect-engineered superconductors

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    We apply the vortex path model of critical currents to a comprehensive analysis of contemporary data on defect-engineered superconductors, showing that it provides a consistent and detailed interpretation of the experimental data for a diverse range of materials. We address the question of whether electron mass anisotropy plays a role of any consequence in determining the form of this data and conclude that it does not. By abandoning this false interpretation of the data, we are able to make significant progress in understanding the real origin of the observed behavior. In particular, we are able to explain a number of common features in the data including shoulders at intermediate angles, a uniform response over a wide angular range and the greater discrimination between individual defect populations at higher fields. We also correct several misconceptions including the idea that a peak in the angular dependence of the critical current is a necessary signature of strong correlated pinning, and conversely that the existence of such a peak implies the existence of correlated pinning aligned to the particular direction. The consistency of the vortex path model with the principle of maximum entropy is introduced.Comment: 14 pages, 7 figure

    Single and Many Particle Correlation Functions and Uniform Phase Bases for Strongly Correlated Systems

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    The need for suitable many or infinite fermion correlation functions to describe some low dimensional strongly correlated systems is discussed. This is linked to the need for a correlated basis, in which the ground state may be postive definite, and in which single particle correlations may suffice. A particular trial basis is proposed, and applied to a certain quasi-1D model. The model is a strip of the 2D square lattice wrapped around a cylinder, and is related to the ladder geometries, but with periodic instead of open boundary conditions along the edges. Analysis involves a novel mean-field approach and exact diagonalisation. The model has a paramagnetic region and a Nagaoka ferromagnetic region. The proposed basis is well suited to the model, and single particle correlations in it have power law decay for the paramagnet, where the charge motion is qualitatively hard core bosonic. The mean field also leads to a BCS-type model with single particle long range order.Comment: 23 pages, in plain tex, 12 Postscript figures included. Accepted for publication in J.Physics : Condensed Matte

    Optimal cloud resource auto-scaling for web applications

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    In the on-demand cloud environment, web application providers have the potential to scale virtual resources up or down to achieve cost-effective outcomes. True elasticity and cost-effectiveness in the pay-per-use cloud business model, however, have not yet been achieved. To address this challenge, we propose a novel cloud resource auto-scaling scheme at the virtual machine (VM) level for web application providers. The scheme automatically predicts the number of web requests and discovers an optimal cloud resource demand with cost-latency trade-off. Based on this demand, the scheme makes a resource scaling decision that is up or down or NOP (no operation) in each time-unit re-allocation. We have implemented the scheme on the Amazon cloud platform and evaluated it using three real-world web log datasets. Our experiment results demonstrate that the proposed scheme achieves resource auto-scaling with an optimal cost-latency trade-off, as well as low SLA violations. © 2013 IEEE

    Evolution of Nuclear Shell Structure due to the Pion Exchange Potential

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    The evolution of nuclear shell structure is investigated for the first time within density-dependent relativistic Hartree-Fock theory and the role of π\pi-exchange potential is studied in detail. The energy differences between the neutron orbits \Lrb{\nu1h_{9/2},\nu 1i_{13/2}} in the N=82 isotones and between the proton ones \Lrb{\pi1g_{7/2},\pi1h_{11/2}} in the Z=50 isotopes are extracted as a function of neutron excess N−ZN-Z. A kink around Z=58Z = 58 for the N=82 isotones is found as an effect resulting from pion correlations. It is shown that the inclusion of π\pi-coupling plays a central role to provide realistic isospin dependence of the energy differences. In particular, the tensor part of the π\pi-coupling has an important effect on the characteristic isospin dependence observed in recent experiments.Comment: 4 pages and 4 figure

    Is U3Ni3Sn4 best described as near a quantum critical point?

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    Although most known non-Fermi liquid (NFL) materials are structurally or chemically disordered, the role of this disorder remains unclear. In particular, very few systems have been discovered that may be stoichiometric and well ordered. To test whether U3Ni3Sn4 belongs in this latter class, we present measurements of the x-ray absorption fine structure (XAFS) of polycrystalline and single-crystal U3Ni3Sn4 samples that are consistent with no measurable local structural disorder. We also present temperature-dependent specific heat data in applied magnetic fields as high as 8 T that show features that are inconsistent with the antiferromagnetic Griffiths' phase model, but do support the conclusion that a Fermi liquid/NFL crossover temperature increases with applied field. These results are inconsistent with theoretical explanations that require strong disorder effects, but do support the view that U3Ni3Sn4 is a stoichiometric, ordered material that exhibits NFL behavior, and is best described as being near an antiferromagnetic quantum critical point.Comment: 9 pages, 8 figures, in press with PR
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